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Paramecium Fission, 400X w.m.
Fission may occur as part of the normal vegetative cell cycle. Under certain conditions, it may be preceded by self-fertilization (autogamy), or it may follow conjugation, a sexual phenomenon in which Paramecia of compatible mating types fuse temporarily and exchange genetic material. During conjugation, the micronuclei of each conjugant divide by meiosis and the haploid gametes pass from one cell to the other. The gametes of each organism then fuse to form diploid micronuclei. The old macronuclei are destroyed, and new ones are developed from the new micronuclei.