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Human Esophageal Stomach Junction, 100X H&E, 8um
The gastro-esophageal junction (also known at the esophagogastric junction) is the junction between the esophagus and the stomach, at the lower end of the esophagus. Histological examination reveals abrupt transition between the stratified squamous epithelium of the esophagus and the simple columnar epithelium of the stomach. The human esophagus has a mucous membrane consisting of a tough stratified squamous epithelium without keratin, a smooth lamina propria, and a muscularis mucosae. The muscular layer of the esophagus has two types of muscle. The upper third of the esophagus contains striated muscle, the lower third contains smooth muscle, and the middle third contains a mixture of both.
 Muscle is arranged in two layers: one in which the muscle fibres run longitudinal to the esophagus, and the other in which the fibres encircle the esophagus. These are separated by the myenteric plexus, a tangled network of nerve fibres involved in the secretion of mucus and in peristalsis of the smooth muscle of the esophagus. The esophagus also has an adventitia, but not a serosa. This makes it distinct from many other structures in the gastrointestinal tract.